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Vitamin D deficiency is associated with high COVID-19 mortality

Vitamin D deficiency is associated with high COVID-19 mortality

The Northwestern University team conducted statistical analysis of knowledge from hospitals and clinics in China, France, Germany, Italy, Iran, South Korea , Spain, Switzerland, the uk , and therefore the us .

The researchers pointed out that patients with high COVID-19 mortality rates, such as Italy, Spain and the United Kingdom, had lower levels of vitamin D compared to countries that were not severely affected.

Researchers warn that this does not mean that each of us should use vitamin supplements.

Vadim Backman of Northwestern University said that Although I think it is important to understand the role that vitamin D deficiency may play in high mortality, we do not need to promote vitamin D to everyone. Further research is needed, I hope Our work will inspire interest. These data can also clarify the mechanism of mortality, and if this is proved, it may lead to new therapeutic targets. 

Backman is a professor of biomedical engineering at Northwestern McCormick School of Engineering. Ali Daneshkhah, a postdoctoral research assistant in the Backman laboratory, was the first author of the paper.

After noticing the unexplained COVID-19 mortality differences between countries, Backman and his team were inspired to start testing the vitamin D levels of the deceased. Some people think that the quality of medical care, population age distribution, detection rate, or differences in different strains of coronavirus may be the reason for this situation. But Backman is still skeptical.

Backman said that None of these factors seem to play an important role. The health care system in northern Italy is one of the best in the world. Even the death rate of people of the same age varies. Although the test limits do vary , But even if we study countries or populations with similar test rates, there are still large differences in mortality. On the contrary, we found a significant correlation between vitamin D deficiency and disease. 

By analyzing publicly available patient data from around the  whole 
world, Backman and his team found an in depth correlation between vitamin D levels and cytokine storms (high inflammatory diseases caused by overactive immune systems), as well as vitamin D deficiency and mortality Correlation.

Daneshkhah said that The cytokine storm can severely damage the lungs and cause acute respiratory distress syndrome and death of patients. This seems to be the cause of death of most patients due to COVID-19, not the destruction of the lungs by the virus itself. This is Complications of misleading inflammation of the immune system. 

This is where Backman believes that vitamin D plays an important role. Vitamin D not only strengthens our innate immune system, but also prevents our immune system from becoming dangerously overactive. This means that having healthy levels of vitamin D can protect patients from serious complications of COVID-19 and even death.

Backman said that Our analysis shows that it may reduce the mortality rate by half. This will not stop people from getting the virus, but it will reduce complications and prevent the death of infected people.

He believes that this correlation may help explain many of the mysteries surrounding COVID-19, such as why children are less likely to die. Children do not have a fully developed acquired immune system-this is the second line of defense of the immune system and is more likely to overreact.

Backman said that Children mainly rely on their innate immune system. This may explain why their deathrate is lower.

Backman pointed out carefully that people should not take too much vitamin D, because vitamin D may cause negative side effects. He said more research is needed to understand how to use vitamin D most effectively to prevent COVID-19 complications.

It is difficult to mention which dose is that the most beneficial for COVID-19, but it's clear that vitamin D deficiency is harmful, and this will be easily resolved with appropriate supplementation. This may be another key measure to protect vulnerable populations, such as Africa African American and elderly patients.

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